Protein Modification Reagents
Medchemexpress LLC Mal-amido-PEG6-acid | 1334177-79-5 | 99.3% | 1 G
Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Tos-PEG4-acid | 1453117-42-4 | 97.2% | 250 MG
Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables PROTACs to contain two different ligands connected by a linker
- Facilitates targeting of E3 ubiquitin ligase and target proteins
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC NH-bis(C2-PEG2-NH-Boc) | 2182601-69-8 | 99.9% | 50 MG
NH-bis(C2-PEG2-NH-Boc) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, allowing for the exploitation of the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs.
- Functions as a PEG-based PROTAC linker.
- Targets PROTAC linkers and PROTAC pathways.
- Applicable in cancer-programmed cell death.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC HS-PEG3-CH2CH2NH2 hydrochloride | 2863676-86-0 | 95.0% | 100 MG
HS-PEG3-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs utilize two distinct ligands connected by a linker
- Selectively degrades target proteins through the ubiquitin-proteasome system
Medchemexpress LLC Mal-PEG5-NHS ester | 1807537-42-3 | 99.0% | 10 MG
Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are composed of two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether and PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bromoacetamido-PEG4-C2-Boc | 1807521-00-1 | 250 MG
Bromoacetamido-PEG4-C2-Boc is a laboratory chemical (CAS No. 1807521-00-1) primarily utilized in the manufacture of substances. This compound exhibits good stability when stored under recommended conditions and typically appears as a liquid. It possesses a molecular formula of C17H32BrNO7 and a molecular weight of 442.34.
- Suitable for laboratory research and substance manufacturing
- Stable under recommended storage conditions
- Appears as a liquid
- Molecular formula: C17H32BrNO7
- Molecular weight: 442.34
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Shipping at room temperature if less than 2 weeks
Medchemexpress LLC m-PEG5-azide | 1202681-04-6 | >98% | 250 MG
m-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent incorporates an azide group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups. This compound is intended for research use only and has not been validated for medical applications. Recommended storage is at -20°C, sealed, and away from moisture.
- Used in the synthesis of PROTACs
- Features an azide group for click chemistry
- Participates in CuAAC reactions with alkyne-containing molecules
- Can undergo SPAAC reactions with DBCO or BCN groups
- Research use only
Medchemexpress LLC DBCO-PEG4-C2-acid | 1537170-85-6 | 99.2% | 250 MG
DBCO-PEG4-C2-acid is a PEG-based PROTAC linker used in PROTAC synthesis. It is a click chemistry reagent with a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs, which contain two different ligands connected by a linker (one for an E3 ubiquitin ligase and one for the target protein), utilize the intracellular ubiquitin-proteasome system for selective target protein degradation.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide groups in molecules
Medchemexpress LLC Mc-PEG4-Val-Ala-PAB-Exatecan | 99.7% | 1153.21 | C58H69FN8O16 | 5 MG
Mc-PEG4-Val-Ala-PAB-Exatecan is an ADC drug-linker conjugate composed of a cleavable Val-Ala-PAB linker and the DNA topoisomerase I inhibitor Exatecan; supplied for research use in milligram quantities for ADC development and linker-payload studies.
- Purity: 99.7%
- Molecular weight: 1153.21
- Chemical formula: C58H69FN8O16
- Physical state: Solid
- Available in 1 MG, 5 MG, 10 MG, 25 MG, 50 MG, 100 MG
- Storage: -20°C sealed; in solvent -80°C (6 months), -20°C (1 month)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC DBCO-PEG4-Biotin | 1255942-07-4 | 99.5% | 25 MG
DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. It is a versatile biotinylation reagent used for introducing a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction. This reagent contains a DBCO group that can undergo SPAAC with molecules containing azide groups.
- Azadibenzocyclooctyne-biotin derivative
- Contains a biotin group and 4 PEGs
- Versatile biotinylation reagent
- Introduces a biotin moiety to azide-labeled biomolecules
- Uses copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction
- DBCO group can undergo SPAAC with molecules containing azide groups
CONJU PROBE LLC Methyltetrazine-PEG4-oxyamine, 25mg
A heterobifunctional linker containing a methyltetrazine moiety for inverse electron demand Diels-Alder cycloaddition reactions and an oxyamine group for oxime ligation
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 100 MG
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker.
- Can be used in the synthesis of protacs.
Medchemexpress LLC 3,6,9,12,15,18-hexaoxanonadecanoic acid | 16142-03-3 | MFCD30536160 | 99.9% | 310.34 | C13H26O8 | 50 MG
m-PEG5-CH2COOH is a monodisperse PEG linker terminating in a carboxylic acid, designed for use as a non-cleavable linker in antibody-drug conjugates and as a PEG-based linker in PROTAC synthesis.
- Terminal carboxylic acid (-CH2COOH) for straightforward amide coupling to amines.
- PEG5 spacer provides hydrophilicity and flexibility to linker arms.
- High reported purity (99.9%) suitable for research-grade bioconjugation.
- Monodisperse molecular weight 310.34 and formula C13H26O8 for predictable behavior.
- Available in small, research-friendly package sizes such as 50 mg.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG20-CH2CH2COOH | 25 g | CAS 1952360-93-8 | MDL MFCD21363316
Fmoc-NH-PEG20-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1952360-93-8
- MDL: MFCD21363316
- InChIKey: YIKBHNBKAGGRHQ-UHFFFAOYSA-N
- Molecular Weight: 1192.397
- Molecular Formula: C58H97NO24
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64-henicosaoxa-4-azaheptahexacontan-67-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)O
Medchemexpress LLC Propargyl-PEG6-N3 | 1198080-03-3 | MFCD31561110 | >98.0% | C15H27N3O6 | 10MG
Propargyl-PEG6-N3 is a PEG-based linker that contains an azide and a terminal propargyl (alkyne) group, designed for click chemistry and bioconjugation. It is used as a spacer in PROTAC synthesis and in the modular assembly of labeled biomolecules, and should be stored per supplier recommendations.